Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease

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Cross-Frequency Phase–Phase Coupling between Theta and Gamma Oscillations in the Hippocampus

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On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

Phase-amplitude coupling between theta and multiple gamma sub-bands is a hallmark of hippocampal activity and believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit phase-phase coupling, or n:m phase-locking, suggesting an important mechanism of neuronal coding that has long received theoretical support. However, by analyzing simu...

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Deep brain stimulation (DBS) has been shown to be an effective treatment for neurologic disorders such as Parkinson’s disease (PD) (1) and psychiatric disorders such as obsessive-compulsive disorder (OCD) (2). However, the mechanisms underlying the therapeutic benefits of DBS are still unclear. A recent groundbreaking study reported that DBS of the basal ganglia in patients with PD is able to s...

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ژورنال

عنوان ژورنال: Brain

سال: 2020

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awaa297